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Samuel R Denmeade Selected Research

CEP 751

1/2006Activity of irinotecan and the tyrosine kinase inhibitor CEP-751 in medullary thyroid cancer.
9/2003CEP-701 and CEP-751 inhibit constitutively activated RET tyrosine kinase activity and block medullary thyroid carcinoma cell growth.
2/2002Trk receptor inhibition induces apoptosis of proliferating but not quiescent human osteoblasts.

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Samuel R Denmeade Research Topics

Disease

96Prostatic Neoplasms (Prostate Cancer)
07/2022 - 02/2002
50Neoplasms (Cancer)
07/2022 - 03/2003
10Neoplasm Metastasis (Metastasis)
11/2020 - 09/2007
5Disease Progression
01/2021 - 03/2013
5Circulating Neoplastic Cells
10/2019 - 03/2010
5Carcinoma (Carcinomatosis)
06/2016 - 08/2006
3Prostatic Hyperplasia (Benign Prostatic Hyperplasia)
11/2020 - 05/2011
3Renal Cell Carcinoma (Grawitz Tumor)
01/2020 - 07/2003
2Fatigue
01/2021 - 08/2006
2Pain (Aches)
01/2020 - 04/2013
2Breast Neoplasms (Breast Cancer)
06/2016 - 07/2012
2Lower Urinary Tract Symptoms
04/2013 - 05/2011
2Prostatic Diseases
11/2011 - 03/2007
2Colonic Neoplasms (Colon Cancer)
02/2009 - 07/2003
2Exanthema (Rash)
03/2007 - 08/2006
1Obesity
01/2021
1Non-alcoholic Fatty Liver Disease
01/2021
1Chronic Disease (Chronic Diseases)
01/2021
1Turcot syndrome
01/2020
1Zoonoses
01/2020
1DNA Repair-Deficiency Disorders (Chromosome Instability Syndromes)
01/2019

Drug/Important Bio-Agent (IBA)

37AndrogensIBA
07/2022 - 03/2003
29Prostate-Specific Antigen (Semenogelase)IBA
10/2021 - 06/2003
23Androgen Receptors (Androgen Receptor)IBA
06/2021 - 05/2009
22ProdrugsIBA
12/2021 - 07/2003
19Peptides (Polypeptides)IBA
01/2021 - 07/2003
16Testosterone (Sustanon)FDA Link
07/2022 - 07/2006
16Proteins (Proteins, Gene)FDA Link
10/2021 - 06/2003
16Serine Proteases (Serine Protease)IBA
04/2018 - 01/2005
13Peptide Hydrolases (Proteases)FDA Link
12/2021 - 07/2003
10ThapsigarginIBA
12/2021 - 07/2003
10AntigensIBA
10/2021 - 06/2004
10enzalutamideIBA
01/2021 - 09/2014
10Biomarkers (Surrogate Marker)IBA
01/2016 - 02/2007
8Pharmaceutical PreparationsIBA
01/2021 - 07/2007
8abirateroneIBA
01/2021 - 09/2014
6Cytotoxins (Cytolysins)IBA
01/2021 - 03/2006
6Hormones (Hormone)IBA
01/2021 - 09/2007
6LigandsIBA
01/2019 - 03/2003
5Docetaxel (Taxotere)FDA Link
11/2014 - 08/2006
4EnzymesIBA
01/2021 - 12/2009
4Biological ProductsIBA
11/2020 - 03/2008
4PRX302IBA
11/2020 - 03/2007
4EmetineIBA
12/2017 - 09/2012
3Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
01/2018 - 03/2008
3Paclitaxel (Taxol)FDA LinkGeneric
06/2016 - 02/2004
3Kallikreins (Kallikrein)IBA
11/2011 - 04/2009
3L12ADTIBA
11/2007 - 07/2003
3lestaurtinibIBA
09/2007 - 02/2002
3CEP 751IBA
01/2006 - 02/2002
2CytokinesIBA
12/2021 - 01/2018
2Aspartate Aminotransferases (Aspartate Transaminase)IBA
01/2021 - 03/2007
2Alanine Transaminase (SGPT)IBA
01/2021 - 03/2007
2Androgen Antagonists (Antiandrogens)IBA
01/2020 - 01/2018
2Prednisone (Sone)FDA LinkGeneric
01/2019 - 03/2010
2Transforming Growth Factor beta (TGF-beta)IBA
01/2018 - 03/2008
2Messenger RNA (mRNA)IBA
07/2017 - 09/2014
2taxaneIBA
07/2017 - 08/2015
2Prolyl OligopeptidasesIBA
09/2014 - 09/2012
2proaerolysinIBA
04/2013 - 08/2007
2Calcium-Transporting ATPases (Ca2+ ATPase)IBA
06/2012 - 04/2005
2Dutasteride (Avodart)FDA Link
11/2009 - 07/2006
2Amino AcidsFDA Link
05/2009 - 05/2009
2Protease Inhibitors (Protease Inhibitor)IBA
07/2008 - 11/2007
2Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
03/2007 - 09/2003
2Differentiation AntigensIBA
02/2007 - 03/2003
2Tissue Kallikreins (Tissue Kallikrein)IBA
03/2006 - 11/2004
1ChemokinesIBA
12/2021
1Nucleic AcidsIBA
12/2021
1sipuleucel-T (APC8015)FDA Link
10/2021
1VaccinesIBA
10/2021
1AntibodiesIBA
10/2021
1prostatic acid phosphataseIBA
10/2021
1Adenosine Triphosphatases (ATPase)IBA
01/2021
1GlucuronidesIBA
01/2021
1Fatty Acids (Saturated Fatty Acids)IBA
01/2021
1GlobulinsIBA
01/2021
1LactonesIBA
01/2021
1SesquiterpenesIBA
01/2021
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2021
1LipidsIBA
01/2021
1Estradiol (Delestrogen)FDA LinkGeneric
01/2021
1Gonadal Steroid Hormones (Sex Hormones)IBA
01/2021
1SteroidsIBA
01/2021
1Glycosylphosphatidylinositols (Glycosyl-Phosphatidylinositol)IBA
11/2020
1Polylactic Acid-Polyglycolic Acid CopolymerIBA
11/2020
1GPI-Linked ProteinsIBA
11/2020
1DNA (Deoxyribonucleic Acid)IBA
01/2020
1Immune Checkpoint InhibitorsIBA
01/2020
1Radium-223IBA
01/2019
1NiclosamideFDA Link
01/2019

Therapy/Procedure

63Therapeutics
07/2022 - 07/2003
37Castration
07/2022 - 07/2006
5Drug Therapy (Chemotherapy)
06/2016 - 07/2003
4Immunotherapy
01/2020 - 11/2011
2Injections
01/2021 - 03/2007
2Radiotherapy
01/2020 - 03/2007
2Prostatectomy (Retropubic Prostatectomy)
01/2019 - 03/2007
1Combination Drug Therapy (Combination Chemotherapy)
07/2022
1Heterologous Transplantation (Xenotransplantation)
01/2020